clausenamide相关论文
Transport and uptake of clausenamide enantiomers in CYP3A4-transfected Caco-2 cells: an insight into
Ain The present study developed a CYP3A4expressed Caco2 monolayer model at which effects of the effluxmetabolism allianc......
Numerousdrugshavebeenstudiedfortheirabilitytorestorecognitivedisorders,inparticularinageasociatedmemoryimpairment(AAMI)andA...
Numerousdrugshavebeenstudiedfortheirabilitytorestorecognitivedisorders, inparticularinage asoci memorymemo......
目的:研究l黄皮酰胺诱导麻醉大鼠海马齿状回长时程增强(LTP)的机制.方法与结果:细胞外记录麻醉大鼠海马齿状回诱发电位.脑室注射纳洛酮1nmol对其......
,Different effects of nine clausenamide ennatiomers on liver glutathione biosynthesis and glutathion
Aim: To study the effects of nine synthetic clausenamide with different stereo structures on liver glutathione (GSH) bio......
Study on the Intramolecular Cyclization through Opening of Epoxide Ⅳ. Cyclization of N-Methyl-N-benz
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
(+)CM1, (-)CM1 as well as (±)CM1–the metabolites of clausenamide were synthesized from (-phenyl-(N-p-methoxylbenzyl)-e......
Study on the Intramolecular Cyclization through Opening of Epoxide Ⅳ. Cyclization of N-Methyl-N-benz
Intramolecular cyclization of β -methyl substituted epoxide under aprotics (e.g. LDA in benzene) and protic conditions ......
【目的】利用纳米技术,将黄皮酰胺(Clausenamide)制备成纳米微乳剂,增强其在使用环境中的稳定性,延长药效并提高其生物活性和防治......
黄皮酰胺是类似脑复康结构的一种化合物。实验表明po能明显延长小鼠断头后的张口呼吸时间和sc亚硝酸钠225 mg/kg后的动物存活时间......
目的:研究黄皮酰胺的主要代谢途径,为进一步研究黄皮酰胺代谢的立体选择性打下基础:方法,用大鼠肝微粒体体外温孵法对右旋黄皮酰胺进行......
根据推测的生源关系,以仿生路线合成了有保肝活性的植物成分黄皮酰胺。...
用[^3H]M-801放射配体竞争结合法国(-),(+)黄皮酰胺对大鼠前脑,海马,皮层等部位突触膜的NMDA-R的作用,以探讨其促智机制。同时用饱和实验分析po给药10d后,小鼠脑内该......
采用细胞外电生理记录法记录了低频刺激所诱发的麻醉大鼠海马状回颗粒细胞层群峰电位并比较了侧脑室注射(-),(+)黄皮酰胺对PS及强直刺激所诱......
目的 研究黄皮酰胺对自由活动大鼠海马齿状回突触传递功能的作用。方法 采用细胞外电生理记录技术。结果 一次性施加HFS能稳定诱导......
目的研究黄皮酰胺(clausenamide,Clau)对映体在大鼠肝微粒体中的酶促反应动力学并比较其立体选择性差异.方法应用反相HPLC法测定Cl......
目的以β-环糊精(β-CD)对黄皮酰胺(Clausenamide,CLA)进行包合.方法采用饱和溶液法制备CLA-β-CD包合物,测定其包封率及载药量,差......
目的观察合成的4-苯基卤代黄皮酰胺衍生物对四氯化碳(CCl4)和D-半乳糖(D-gal)致小鼠急性肝损伤的影响。方法4-苯基卤代黄皮酰胺衍生物......
目的:探讨大黄素结合黄皮酰胺治疗老年性痴呆的临床疗效。方法:将2012年6月-2013年1月在我院脑病科治疗的87例老年痴呆患者作为研究......
以相同的肝微粒体温孵体系对(+)-和(-)-黄皮酰胺(Cla)进行了温孵,以HPLC分析比较了代谢结果,发现(+)和(-)Cla所产生的主要代谢产物基本相同,但主要代谢产物在(+)-和(-)-Cla温......
黄皮酰胺是从中药黄皮叶中提取到的天然成分,现已完成其16个光学活性异构体的合成和拆分。通过对其中一对对映体(-)黄皮酰胺和(+)黄皮酰......
Synthesis of the optically active metabolite of clausenamide CM2 (3, 5-dihydroxy- 5-(α-hydroxylbenzyl)-1-methyl-4-benzy......
黄皮酰胺是从传统中药黄皮叶中分离出来的一种天然产物,具有良好的保肝和促智活性。为了给生物学评价提供样品,并进行深入的构效关系......
Transport and uptake of clausenamide enantiomers in CYP3A4-transfected Caco-2 cells: an insight into
Aim The present study developed a CYP3A4-expressed Caco-2 monolayer model at which effects of the efflux-metabolism alli......
(+)CM1, (-)CM1 as well as (±)CM1–the metabolites of clausenamide were synthesized from (-phenyl-(N-p-methoxylbenzy......